Latanoprost (Lexi-Drugs)

Drug Shortages

One or more forms of this drug may be in short supply or unavailable. Refer to the following for additional information:

ASHP: http://www.ashp.org/menu/DrugShortages

Pronunciation

(la TA noe prost)

Brand Names: US

Xalatan; Xelpros

Brand Names: Canada

APO-Latanoprost; GD-Latanoprost; MED-Latanoprost; Monoprost; PMS-Latanoprost; RIVA-Latanoprost; SANDOZ Latanoprost; TEVA-Latanoprost; Xalatan

Dosing: Adult

Elevated intraocular pressure: Ophthalmic: One drop in the affected eye(s) once daily in the evening; do not exceed the once daily dosage (may decrease the IOP-lowering effect)

Dosing: Geriatric

Refer to adult dosing.

Dosing: Renal Impairment: Adult

There is no dosage adjustment provided in manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Adult

There is no dosage adjustment provided in manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Pediatric

Reduction of intraocular pressure: Limited data available: Infants, Children, and Adolescents: 1 drop to affected eye(s) once daily in the evening (Maeda-Chubachi 2013; Quaranta 2017)

Dosing: Renal Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling; however, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling; however, dosage adjustment unlikely due to low systemic absorption.

Use: Labeled Indications

Elevated intraocular pressure: Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension.

Administration: Ophthalmic

May be used with other eye drops to lower IOP. If more than one topical ophthalmic drug is being used, administer the drugs at least 5 minutes apart. Remove contact lenses prior to administration and wait 15 minutes before reinserting.

Administration: Pediatric

Ophthalmic: Wash hands before use. Unscrew the cap by turning in the direction of the arrows on top of the cap. Pull lower eyelid down slightly to form a pocket for the eye drop and tilt head back; administer 1 drop. Apply gentle pressure to lacrimal sac immediately following instillation (1 minute) or instruct patient to gently close eyelid after administration to decrease systemic absorption of ophthalmic drops (Urtti 1993; Zimmerman 1982). Avoid contact of bottle tip with skin or eye; remove contact lenses prior to administration and wait at least 15 minutes after instillation before reinserting soft contact lenses. If more than one topical ophthalmic drug is being used, separate administration by at least 5 minutes.

Storage/Stability

Emulsion: Store at 2°C to 25°C (36°F to 77°F). Protect from light. May be maintained at temperatures up to 40°C (104°F) for up to 8 days during shipment.

Solution: Store intact bottles under refrigeration at 2°C to 8°C (36°F to 46°F). Protect from light. Once opened, the container may be stored at room temperature up to 25°C (77°F) for 6 weeks.

Medication Patient Education with HCAHPS Considerations

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience blurred vision, burning, stinging, eyelash changes, or foreign body sensation in eye. Have patient report immediately to prescriber vision changes, eye pain, severe eye irritation, eye discharge, or eye discoloration (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

Medication Safety Issues
  Sound-alike/look-alike issues:
Contraindications

Hypersensitivity to latanoprost, benzalkonium chloride, or any component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Bacterial keratitis: Inadvertent contamination of multiple-dose ophthalmic solutions, has caused bacterial keratitis.

• Ocular effects: May change/increase brown pigmentation of the iris, the eyelid skin, and eyelashes; length and/or number of eyelashes may also be increased. Pigmentation of the iris is likely to be permanent although iris color change may not be noticeable for months to years; pigmentation of the periorbital tissue and eyelash changes may be reversible following discontinuation of therapy. Long-term consequences and potential injury to eye are not known.

• Ocular inflammation: Intraocular inflammation and exacerbation of inflammation may occur; use with caution in patients with a history of intraocular inflammation (eg, iritis/uveitis) and generally avoid use in patients with active intraocular inflammation.

Disease-related concerns:

• Herpetic keratitis: Use with caution in patients with a history of herpes simplex keratitis; reactivation may occur. Avoid use in patients with active herpes simplex keratitis.

• Ocular disease: Use with caution in aphakic patients, pseudophakic patients with a torn posterior lens capsule, or patients with risk factors for macular edema. Safety and efficacy have not been determined for use in patients with angle-closure, inflammatory, or neovascular glaucoma.

Special populations:

• Contact lens wearers: Solution contains benzalkonium chloride which may be absorbed by contact lenses; remove contacts prior to administration and wait 15 minutes before reinserting.

Geriatric Considerations

Evaluate the patient’s or caregiver’s ability to safely administer the correct dose of ophthalmic medication.

Pregnancy Considerations

Information related to use in pregnancy is limited (DeSantis 2004).

In general, if ophthalmic agents are needed in pregnancy, the minimum effective dose should be used in combination with punctal occlusion to decrease exposure to the fetus (Samples 1988).

Breast-Feeding Considerations

It is not known if latanoprost is present in breast milk.

According to the manufacturer, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother.

Briggs’ Drugs in Pregnancy & Lactation
Adverse Reactions

>10%:

Central nervous system: Foreign body sensation of eye (2% to 13%)

Ophthalmic: Eye pain (≤55%), stinging of eyes (≤55%), ocular hyperemia (41%), conjunctival hyperemia (8% to 15%), eye discharge (12%), increased eyelash length (11%)

1% to 10%:

Dermatologic: Erythema of eyelid (3%), hyperpigmentation of eyelashes (1%), allergic skin reaction (≤1%, including eyelid), skin rash (≤1%)

Infection: Influenza (≤3%)

Neuromuscular & skeletal: Arthralgia (≤1%), back pain (≤1%), myalgia (≤1%)

Ophthalmic: Punctate keratitis (1% to 10%), blurred vision (8%), increased eyelash thickness (8%), eye pruritus (5% to 8%), burning sensation of eyes (7%), iris hyperpigmentation (7%), decreased visual acuity (4%), eyelid pain (4%), lacrimation (4%), crusting of eyelid (3%), dry eye syndrome (3%), photophobia (2%), eyelid edema (1% to 2%), conjunctival edema (1%)

Respiratory: Nasopharyngitis (≤3%), upper respiratory tract infection (≤3%)

<1%, postmarketing, and/or case reports: Angina pectoris, asthma, bacterial keratitis, chest pain, conjunctivitis (including pseudopemphigoid of the ocular conjunctiva), corneal edema, corneal erosion, dizziness, dyspnea, exacerbation of asthma, eye disease (periorbital and lid changes resulting in deepening of the eyelid sulcus), headache, herpes simplex keratitis, hyperpigmentation of eyelids, increased growth in number of eyelashes, iris cyst, iritis, keratitis, macular edema (including cystoid macular edema), misdirected growth of eyelashes (including trichiasis), palpitations, pruritus, toxic epidermal necrolysis, unstable angina pectoris, uveitis

Metabolism/Transport Effects

None known.

Drug Interactions 

Bimatoprost: The concomitant use of Latanoprost and Bimatoprost may result in increased intraocular pressure. Risk C: Monitor therapy

Nonsteroidal Anti-Inflammatory Agents: May diminish the therapeutic effect of Prostaglandins (Ophthalmic). Nonsteroidal Anti-Inflammatory Agents may also enhance the therapeutic effects of Prostaglandins (Ophthalmic). Risk C: Monitor therapy

Nonsteroidal Anti-Inflammatory Agents (Ophthalmic): May diminish the therapeutic effect of Prostaglandins (Ophthalmic). Nonsteroidal Anti-Inflammatory Agents (Ophthalmic) may enhance the therapeutic effect of Prostaglandins (Ophthalmic). Risk C: Monitor therapy

Monitoring Parameters

Monitor IOP; regularly examine patients who develop increased iris pigmentation.

Advanced Practitioners Physical Assessment/Monitoring

Monitor for blurred vision, burning and stinging, conjunctival hyperemia, foreign body sensation, itching, increased pigmentation of the iris, and punctate epithelial keratopathy.

Nursing Physical Assessment/Monitoring

Monitor for blurred vision, burning and stinging, conjunctival hyperemia, foreign body sensation, itching, increased pigmentation of the iris, and punctate epithelial keratopathy.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Emulsion, Ophthalmic:

Xelpros: 0.005% (2.5 mL) [contains edetate disodium, propylene glycol]

Solution, Ophthalmic:

Xalatan: 0.005% (2.5 mL) [contains benzalkonium chloride]

Generic: 0.005% (2.5 mL)

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic:

Monoprost: 0.005% (0.2ml) [contains EDETATE DISODIUM]

Xalatan: 0.005% (2.5ml) [contains BENZALKONIUM CHLORIDE]

Generic: 0.005% (2.5ml, 5ml)

Anatomic Therapeutic Chemical (ATC) Classification
  • S01EE01
Generic Available (US)

May be product dependent

Pricing: US

Emulsion (Xelpros Ophthalmic)

0.005% (per mL): $26.40

Solution (Latanoprost Ophthalmic)

0.005% (per mL): $6.00 – $38.11

Solution (Xalatan Ophthalmic)

0.005% (per mL): $97.82

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer’s AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Mechanism of Action

Latanoprost is a prostaglandin F2-alpha analog believed to reduce intraocular pressure by increasing the outflow of the aqueous humor

Pharmacodynamics/Kinetics

Onset of action: 3 to 4 hours

Peak effect: Maximum: 8 to 12 hours

Absorption: Through the cornea where the isopropyl ester prodrug is hydrolyzed by esterases to the biologically active acid. Peak concentration is reached in 2 hours after topical administration in the aqueous humor.

Distribution: Vd: 0.16 ± 0.02 L/kg

Metabolism: Primarily hepatic via fatty acid beta-oxidation

Half-life elimination: 17 minutes

Excretion: Urine (as metabolites)

Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Effects on Dental Treatment

No significant effects or complications reported

Effects on Bleeding

No information available to require special precautions

FDA Approval Date
June 05, 1996
References

De Santis M, Lucchese A, Carducci B, et al. Latanoprost exposure in pregnancy. Am J Ophthalmol. 2004;138(2):305-306. doi: 10.1016/j.ajo.2004.03.002.[PubMed 15289149]

Monoprost (latanoprost) [prescribing information]. Oakville, Ontario, Canada: Labtician Ophthalmics Inc.; July 2016.

Patel SS and Spencer CM, “Latanoprost: A Review of Its Pharmacological Properties, Clinical Efficacy and Tolerability in the Management of Primary Open-Angle Glaucoma and Ocular Hypertension,” Drugs Aging, 1996, 9(5):363-78.[PubMed 8922563]

Samples JR, Meyer SM. Use of ophthalmic medications in pregnant and nursing women. Am J Ophthalmol. 1988;106(5):616-623.[PubMed 2903673]

Xalatan (latanoprost) [prescribing information]. New York, NY: Pfizer; April 2017.

Xalatan (latanoprost) [prescribing information]. New York, NY: Pfizer; September 2018.

Xelpros (latanoprost) [prescribing information]. Cranbury, NJ: Sun Pharmaceuticals; September 2018.

Brand Names: International

9 PM eye drops (IN); Akistan (AT, CZ, DE, HU, PL); Arulatan (BG, BR, EE, ES, SK); Ciptan (HU); Drenatan (BR); Enicil (PT); Exalo (MX); Exprosol (NL); Gaap Ofteno (CR, DO, GT, HN, NI, PA, SV); Glaumax (EE); Glautan (IL); Hysite Eye Drops (NZ); Ioprost (EG); Iprost (BD); Jaskroptic (PL); Kivixkenl (MX); Lanoprost (TW); Lanotan (KR, TH, UA); Laprost (DE, VE); Latacris (AT, IE, PL); Latalux (CZ, LT, LV, SK); Latano (BH, ET); Latanoflax (CO); Latanopress (VE); Latanox (CO, EG, UA); Latapres (BD, HR); Lataprost (MY); Lataro (KR); Lataz (TR); Latep (LK); Latipress (ID, PH); Latizodil (LV); Latnoprost (AU); Latnot (AU); Latochek (SG); Latof (PY, UY); Latop (IE); Latoprost (LK); Louten (AR, BR, CL, EC, LB, PE, PY, UY); Lumoprost (TH); Monopost (AT, CZ, DE, DK, GB, IE, LT); Monoprost (BE, BG, CL, ES, NL, PT); Ocuprost (BD, PE); Pioprost (CR, DO, GT, HN, NI, PA, SV); Prosdrop (TH); Protan (KR); Rasguna (CR, DO, GT, HN, NI, PA, SV); Tonlit (ES); Unilat (EE, HR, HU, LT, RO); Vislat (LK); Vizilat (BG); Vizilatan (CZ, NL); Xalaprost (AU, BD, MT); Xalatan (AE, AR, AT, AU, BB, BE, BG, BH, BO, BR, CH, CL, CN, CO, CR, CY, CZ, DE, DK, DO, EE, EG, ES, FI, FR, GB, GR, GT, HK, HN, HR, HU, ID, IE, IL, IN, IQ, IR, IS, IT, JO, KR, KW, LB, LT, LU, LV, LY, MT, MX, MY, NI, NL, NO, OM, PA, PE, PH, PK, PL, PR, PT, QA, RO, RU, SA, SE, SG, SI, SK, SV, SY, TH, TR, TW, UA, UY, VE, VN, YE, ZA, ZW); Xalavist (PH); Xalof (BE); Xaloftal (BR); Xanopt (AU); Xaprost (TH)

Latanoprost (Patient Education – Adult Medication)
You must carefully read the “Consumer Information Use and Disclaimer” below in order to understand and correctly use this information
Pronunciation

(la TA noe prost)

Brand Names: US

Xalatan; Xelpros

Brand Names: Canada

Monoprost; Xalatan

What is this drug used for?
  • It is used to treat glaucoma.
  • It is used to lower high eye pressure.
What do I need to tell my doctor BEFORE I take this drug?
  • If you have an allergy to latanoprost or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have swelling in the eye.
  • If you have a herpes infection of the eye.
  • If you are using another drug like this one.
  • This is not a list of all drugs or health problems that interact with this drug.
  • Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take this drug?
  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • Use care when driving or doing other tasks that call for clear eyesight.
  • Have your eye pressure and eyesight checked as you have been told by the doctor.
  • Tell your doctor if you have an eye infection, eye injury, or will be having eye surgery.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
What are some side effects that I need to call my doctor about right away?
  • WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Eye discharge.
  • Eye color may change to a brown color. This change may be long-lasting. Eye color changes may happen a few months to years after starting this drug. If eye color changes, call the doctor.
What are some other side effects of this drug?
  • All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Eye irritation.
  • Blurred eyesight.
  • Burning.
  • Stinging.
  • Eyelash growth.
  • Feeling that something is in the eye.
  • This drug may cause eyelash changes like dark eyelashes, thickness, or more eyelashes. Most of the time, these changes go back to normal after this drug is stopped.
  • These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
  • You may report side effects to your national health agency.
How is this drug best taken?
  • Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
  • For the eye only.
  • To gain the most benefit, do not miss doses.
  • Use in the evening.
  • Wash your hands before and after use.
  • Take out contact lenses before using this drug. Lenses may be put back in 15 minutes after this drug is given. Do not put contacts back in if your eyes are irritated or infected.
  • Do not touch the container tip to the eye, lid, or other skin.
  • Tilt your head back and drop drug into the eye.
  • After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.
  • Blot extra solution from the eyelid.
  • If more than 1 drug is being used in the same eye, use each drug at least 5 minutes apart.
What do I do if I miss a dose?
  • Skip the missed dose and go back to your normal time.
  • Do not use 2 doses at the same time or extra doses.
How do I store and/or throw out this drug?
  • Eye drops (solution):
  • Store unopened bottles in the refrigerator. Do not freeze.
  • Store opened bottles at room temperature. Throw away any part not used after 6 weeks.
  • Eye drops (emulsion):
  • Store in a refrigerator or at room temperature.
  • All products:
  • Store in a dry place. Do not store in a bathroom.
  • Protect from light.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
General drug facts
  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Latanoprost (Patient Education – Pediatric Medication)
You must carefully read the “Consumer Information Use and Disclaimer” below in order to understand and correctly use this information
Pronunciation

(la TA noe prost)

Brand Names: US

Xalatan; Xelpros

Brand Names: Canada

Monoprost; Xalatan

What is this drug used for?
  • It is used to lower high eye pressure.
  • This drug is not approved for use in children. However, the doctor may decide the benefits of taking this drug outweigh the risks. If your child has been given this drug, ask the doctor for information about the benefits and risks. Talk with the doctor if you have questions about giving this drug to your child.
What do I need to tell the doctor BEFORE my child takes this drug?
  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child has swelling in the eye.
  • If your child has a herpes infection of the eye.
  • If your child is using another drug like this one.
  • This is not a list of all drugs or health problems that interact with this drug.
  • Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.
What are some things I need to know or do while my child takes this drug?
  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
  • Have your child use care when doing tasks that call for clear eyesight.
  • Have your child’s eye pressure and eyesight checked as you have been told by the doctor. Talk with the doctor.
  • Tell the doctor if your child has an eye infection, eye injury, or will be having eye surgery.
  • If your child is pregnant or breast-feeding a baby:
  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks to your child and the baby.
What are some side effects that I need to call my child’s doctor about right away?
  • WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Eye discharge.
  • Eye color may change to a brown color. This change may be long-lasting. Eye color changes may happen a few months to years after starting this drug. If eye color changes, call the doctor.
What are some other side effects of this drug?
  • All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Eye irritation.
  • Blurred eyesight.
  • Burning.
  • Stinging.
  • Eyelash growth.
  • Feeling that something is in the eye.
  • This drug may cause eyelash changes like dark eyelashes, thickness, or more eyelashes. Most of the time, these changes go back to normal after this drug is stopped.
  • These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
  • You may report side effects to your national health agency.
How is this drug best given?
  • Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
  • For the eye only.
  • To gain the most benefit, do not miss giving your child doses.
  • Give in the evening.
  • Wash your hands before and after use.
  • Have your child take out his/her contact lenses before using this drug. Lenses may be put back in 15 minutes after this drug is given. Do not put lenses back in if your child’s eyes are irritated or infected.
  • Do not touch the container tip to the eye, lid, or other skin.
  • Tilt your child’s head back and drop drug into the eye.
  • After giving this drug, ask your child to keep eyes closed. Put light pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your child’s eye.
  • Blot extra solution from the eyelid.
  • If more than 1 drug is being used in the same eye, use each drug at least 5 minutes apart.
What do I do if my child misses a dose?
  • Skip the missed dose and go back to your child’s normal time.
  • Do not give 2 doses at the same time or extra doses.
How do I store and/or throw out this drug?
  • Eye drops (solution):
  • Store unopened bottles in the refrigerator. Do not freeze.
  • Store opened bottles at room temperature. Throw away any part not used after 6 weeks.
  • Store in a dry place. Do not store in a bathroom.
  • Protect from light.
  • Eye drops (emulsion):
  • Store at room temperature or in a refrigerator. Do not freeze.
  • All products:
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
General drug facts
  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.